Detection of Murine TRPA1 Transcripts in Keratinocytes

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To Cite : Kwan K Y. Detection of Murine TRPA1 Transcripts in Keratinocytes, J Skin Stem Cell. 2016 ;3(1):e32521. doi: 10.5812/jssc.32521.
Copyright: Copyright © 2016, Journal of Skin and Stem Cell. .
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Lumpkin EA, Caterina MJ. Mechanisms of sensory transduction in the skin. Nature. 2007; 445(7130): 858-65[DOI][PubMed]
  • 2. Denda M, Nakatani M, Ikeyama K, Tsutsumi M, Denda S. Epidermal keratinocytes as the forefront of the sensory system. Exp Dermatol. 2007; 16(3): 157-61[DOI][PubMed]
  • 3. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012; 166(2): 510-21[DOI][PubMed]
  • 4. Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch. 2009; 458(6): 1093-102[DOI][PubMed]
  • 5. Corey DP. New TRP channels in hearing and mechanosensation. Neuron. 2003; 39(4): 585-8[PubMed]
  • 6. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003; 112(6): 819-29[PubMed]
  • 7. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006; 124(6): 1269-82[DOI][PubMed]
  • 8. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006; 50(2): 277-89[DOI][PubMed]
  • 9. Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, et al. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 2005; 307(5714): 1468-72[DOI][PubMed]
  • 10. Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL. TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci. 2009; 29(15): 4808-19[DOI][PubMed]
  • 11. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, et al. A heat-sensitive TRP channel expressed in keratinocytes. Science. 2002; 296(5575): 2046-9[DOI][PubMed]
  • 12. Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ. TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem. 2004; 279(20): 21569-75[DOI][PubMed]
  • 13. Sellers RF. Possible windborne spread of myxomatosis to England in 1953. Epidemiol Infect. 1987; 98(1): 119-25[PubMed]
  • 14. Atoyan R, Shander D, Botchkareva NV. Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol. 2009; 129(9): 2312-5[DOI][PubMed]
  • 15. Denda M, Tsutsumi M, Goto M, Ikeyama K, Denda S. Topical application of TRPA1 agonists and brief cold exposure accelerate skin permeability barrier recovery. J Invest Dermatol. 2010; 130(7): 1942-5[DOI][PubMed]
  • 16. Lichti U, Anders J, Yuspa SH. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc. 2008; 3(5): 799-810[DOI][PubMed]
  • 17. Lyle WH. Letter: D-penicillamine and haemolytic anaemia. Lancet. 1976; 1(7956): 428[PubMed]
  • 18. Forbes GB. Publication time. Am J Dis Child. 1974; 128(3): 293-4[PubMed]
  • 19. Hendy MS, Beattie BE, Burge PS. Occupational asthma due to an emulsified oil mist. Br J Ind Med. 1985; 42(1): 51-4[PubMed]
  • 20. Cox JC, Aasa R, Malmstrom BG. EPR studies on the blue copper protein, rusticyanin: a protein involved in Fe2+ oxidation at pH 2.0 in Thiobacillus ferro-oxidans. FEBS Lett. 1978; 93(1): 157-60[PubMed]
  • 21. Lariviere WR, Wilson SG, Laughlin TM, Kokayeff A, West EE, Adhikari SM, et al. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain. 2002; 97(1-2): 75-86[PubMed]
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